instal the new for windows RJ TextEd 15.96

Ovarian radiotherapy dose was quantified by reconstructing each patient’s individual radiation treatment on a computed tomography (CT)–based phantom with an organ library for calculation of normal organ radiation doses, as performed in other analyses in the SJLIFE protocol. Radiation fields potentially involving the ovaries included the following areas: pelvis, lumbar or sacral or whole spine, flank or abdomen if extending below the iliac crest, inverted Y, para-aortic, iliac, bladder or vaginal, in addition to total lymphoid or total body irradiation ( 9). Ovarian dosimetry and quantification of alkylating agent and glucocorticoid exposures We also evaluated associations between POI and risk factors of cardiovascular disease (abdominal obesity, hypertension, abnormal glucose metabolism, dyslipidemia), as well as low BMD and frailty. The current study reports on the overall prevalence of POI in a large cohort of long-term CCSs and examines associations between host and treatment factors and the development of POI. The contribution of POI to adverse health outcomes and markers of poor physical condition such as frailty in CCSs has not been well established ( 12, 13). In the general population, POI has been associated with an increased risk of cardiovascular disease and low bone mineral density (BMD) ( 10, 11).

Continuous improvements and increased availability of female fertility preservation techniques ( 8), together with the importance of sexual and reproductive outcomes on overall patient health and quality of life, mandate that we have a better understanding of POI and its risk factors ( 4, 9). POI can occur early, during, or immediately following the completion of cancer treatment ( 2) or, more commonly, in the years that follow the completion of cancer treatments but prior to age 40 ( 3).

Primary or secondary amenorrhea may occur depending on the pubertal stage at the time of cancer treatment.

Due to the intricate relationship between the hormone-producing granulosa cells and the oocyte, POI causes disruption of both endocrine and reproductive functions of the ovary. Female childhood cancer survivors (CCSs) are at an increased risk of developing premature ovarian insufficiency (POI) because of the vulnerability of the ovaries to gonadotoxic treatment modalities such as pelvic radiotherapy and alkylating agent chemotherapy ( 1– 7).

Instal the new for windows RJ TextEd 15.96